Opaleye Management 13F annual report

Opaleye Management is an investment fund managing more than $222 million ran by James Silverman. There are currently 47 companies in Mr. Silverman’s portfolio. The largest investments include Harrow Health and Ocular Therapeutix Inc, together worth $48.3 million.

$222 million Assets Under Management (AUM)

As of 8th August 2022, Opaleye Management’s top holding is 3,332,732 shares of Harrow Health currently worth over $24.3 million and making up 10.9% of the portfolio value. Relative to the number of outstanding shares of Harrow Health, Opaleye Management owns more than 0.1% of the company. In addition, the fund holds 5,974,800 shares of Ocular Therapeutix Inc worth $24 million, whose value fell 1.8% in the past six months. The third-largest holding is Codexis worth $13.5 million and the next is Crinetics Pharmaceuticals Inc worth $12.5 million, with 671,300 shares owned.

Currently, Opaleye Management's portfolio is worth at least $222 million. The total portfolio value may be much higher due to cash assets that are not publicly disclosed such as fixed income, real estate, or cash equivalents.

Careers at Opaleye Management

The Opaleye Management office and employees reside in Boston, Massachusetts. According to the last 13-F report filed with the SEC, James Silverman serves as the President at Opaleye Management.

Recent trades

In the most recent 13F filing, Opaleye Management revealed that it had opened a new position in Inhibrx and bought 590,000 shares worth $6.7 million. This means they effectively own approximately 0.1% of the company. Inhibrx makes up 3.2% of the fund's Health Care sector allocation and has decreased its share price by approximately 0.1% in the past year.

The investment fund also strengthened its position in Harrow Health by buying 41,389 additional shares. This makes their stake in Harrow Health total 3,332,732 shares worth $24.3 million. Harrow Health dropped approximately 0.1% in the past year.

On the other hand, there are companies that Opaleye Management is getting rid of from its portfolio. Opaleye Management closed its position in Bicycle Therapeutics plc on 15th August 2022. It sold the previously owned 175,000 shares for $7.68 million. James Silverman also disclosed a decreased stake in Codexis by approximately 0.1%. This leaves the value of the investment at $13.5 million and 1,288,450 shares.

One of the smallest hedge funds

The two most similar investment funds to Opaleye Management are Bcs Wealth Management and Rv Capital Ag. They manage $222 million and $222 million respectively.


James Silverman investment strategy

Opaleye Management’s portfolio is diversified across 2 sectors. Currently, their heaviest sector is Health Care — making up 93.2% of the total portfolio value. The fund focuses on investments in the United States as 70.2% of the portfolio companies are based in the United States.

The majority of the companies in the fund’s portfolio are small-cap stocks. Stocks with a size of more than $100 million in market cap make up 13% of the total holdings value. On the other hand, large-cap stocks make up only approximately 0.1% of the portfolio. The average market cap of the portfolio companies is close to $616 million.

The complete list of Opaleye Management trades based on 13F SEC filings

These positions were updated on August 15th based on the fund’s latest 13F filing. Quickly find out what the most recently closed or increased positions are.

Security Shares Owned Value Allocation
Harrow Health, Inc.
1.26%
3,332,732
$24,262,000 10.94%
Ocular Therapeutix Inc
No change
5,974,800
$24,019,000 10.83%
Codexis Inc.
4.20%
1,288,450
$13,477,000 6.07%
Crinetics Pharmaceuticals Inc
3.13%
671,300
$12,520,000 5.64%
Cytokinetics Inc
25.58%
302,500
$11,885,000 5.36%
TELA Bio, Inc.
244.52%
1,643,367
$11,520,000 5.19%
Protara Therapeutics Inc
0.38%
2,684,167
$8,885,000 4.00%
TRACON Pharmaceuticals Inc
30.75%
4,125,322
$8,251,000 3.72%
Kiniksa Pharmaceuticals Ltd
26.81%
814,250
$7,890,000 3.56%
Bicycle Therapeutics plc
Closed
175,000
$7,679,000
Merus N.V
No change
338,000
$7,652,000 3.45%
Keros Therapeutics, Inc.
3.86%
276,000
$7,626,000 3.44%
Inhibrx, Inc.
Opened
590,000
$6,697,000 3.02%
Eton Pharmaceuticals, Inc.
3.50%
2,462,500
$6,452,000 2.91%
Protagonist Therapeutics Inc
Closed
251,500
$5,956,000
XOMA Corp
2.93%
263,050
$5,861,000 2.64%
Reata Pharmaceuticals Inc
54.85%
183,750
$5,584,000 2.52%
Cutera Inc
Opened
147,700
$5,539,000 2.50%
Mersana Therapeutics Inc
47.46%
1,047,000
$4,837,000 2.18%
Vaxcyte, Inc.
9.95%
190,000
$4,134,000 1.86%
Stereotaxis, Inc.
12.34%
2,099,971
$3,864,000 1.74%
Edgewise Therapeutics Inc
48.98%
451,400
$3,593,000 1.62%
Semler Scientific Inc
Closed
70,000
$3,469,000
908 Devices Inc.
No change
166,406
$3,426,000 1.54%
Fulcrum Therapeutics Inc
Closed
136,000
$3,216,000
Chimerix Inc
75.78%
1,430,000
$2,974,000 1.34%
Fortress Biotech Inc
13.41%
3,247,180
$2,727,000 1.23%
Celldex Therapeutics Inc.
53.96%
90,000
$2,426,000 1.09%
Synlogic Inc
Closed
984,200
$2,362,000
Liquidia Corp
191.67%
521,500
$2,274,000 1.02%
4D Molecular Therapeutics Inc.
No change
325,000
$2,269,000 1.02%
Proqr Therapeutics Nv
12.99%
2,740,000
$2,131,000 0.96%
UroGen Pharma Ltd
Opened
238,670
$1,955,000 0.88%
Ginkgo Bioworks Holdings Inc
12.34%
815,000
$1,940,000 0.87%
Verastem Inc
31.61%
1,590,000
$1,844,000 0.83%
Larimar Therapeutics, Inc.
1.15%
932,814
$1,828,000 0.82%
Hyperfine Inc
No change
763,075
$1,702,000 0.77%
Rhythm Pharmaceuticals Inc.
Opened
362,000
$1,502,000 0.68%
Modular Medical Inc
3.50%
275,422
$1,427,000 0.64%
Impel Pharmaceuticals Inc
Opened
144,642
$1,348,000 0.61%
AVEO Pharmaceuticals Inc
Closed
240,000
$1,342,000
Graphite Bio Inc
80.04%
460,000
$1,265,000 0.57%
Journey Medicine Corp
266.77%
245,733
$919,000 0.41%
NuCana plc
Closed
878,700
$878,000
Repare Therapeutics Inc.
Closed
55,678
$793,000
Sutro Biopharma Inc
Closed
89,980
$740,000
Neoleukin Therapeutics, Inc.
22.78%
610,000
$628,000 0.28%
Macrogenics Inc
44.66%
208,300
$614,000 0.28%
Neuropace Inc
Opened
90,100
$446,000 0.20%
Forma Therapeutics Holdings, Inc.,
Opened
58,700
$404,000 0.18%
OptiNose Inc
Opened
90,970
$333,000 0.15%
Marinus Pharmaceuticals Inc
Opened
68,900
$333,000 0.15%
Avalo Therapeutics Inc
69.06%
450,000
$225,000 0.10%
Theseus Pharmaceuticals Inc
Opened
32,300
$179,000 0.08%
Lumos Pharma Inc
Opened
21,520
$166,000 0.07%
Biolinerx Ltd
No change
16,667
$21,000 0.01%
No transactions found
Showing first 500 out of 56 holdings